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PH20 Variant

GCP310: Next-Generation PH20 Setting a New Standard in Biologic Delivery

Opening a new era of human hyaluronidase with enhanced activity, stability and safety

PH20 

(Human Hyaluronidase PH20)

PH20 is an enzyme that degrades hyaluronic acid in subcutaneous tissues, increasing tissue permeability


This allows the subcutaneous (SC) delivery of 

high-molecular-weight and high-dose biologics, 

which traditionally required intravenous (IV) injection

GCP310 

(Next-Generation PH20)

GeneChem has developed GCP310, a next-generation human hyaluronidase that overcomes the limitations 

of the existing PH20


GCP310 is an engineered enzyme with enhanced 

activity and thermal stability, and reduced 

immunogenicity, offering greater efficiency and 

robustness compared to existing PH20


This innovation enables the conversion of high-dose biologics-previously limited to hospital-administered 

IV or SC infusions-into self-administered 

SC injection formula

Distinctive Features

  • Higher protein expression and enzymatic activity than conventional PH20, enabling cost-effective use through lower enzyme dosage
  • Low immunogenic profile enhances clinical safety
  • Dramatically improved hyaluronan degradation rate and thermal stability for superior reliability and performance
  • Enables self-administered SC formulations, removing the need for IV or hospital-based SC infusion
Company
Expression
Activity
Thermal Stability
Immunogenicity
Company A
+
+
+
Low
Company B
++
++
++
Low
GeneChem
+++
+++
+++
Low

GCP310: Next-Generation PH20 Setting a New Standard
in Biologic Delivery

  • Opening a new era of human hyaluronidase
    with enhanced activity, stability and safety.

PH20
(Human Hyaluronidase PH20)

  • PH20 is an enzyme that degrades
    hyaluronic acid in subcutaneous tissues,
    increasing tissue permeability.
    This allows the subcutaneous (SC) delivery
    of high-molecular-weight and high-dose
    biologics, which traditionally required
    intravenous (IV) injection.

GCP310
(Next-Generation PH20)

GeneChem has developed GCP310,

 a next-generation human hyaluronidase that overcomes the limitations 

of the existing PH20.


GCP310 is an engineered enzyme with enhanced activity and thermal stability,
and reduced immunogenicity, offering greater efficiency and robustness compared to existing PH20.


This innovation enables the conversion of high-dose biologics previously limited to hospital-administered IV or SC infusions into self-administered SC injection formula.

Distinctive Features

Higher protein expression and enzymatic activity than conventional PH20, enabling cost-effective use through lower enzyme dosage.


Low immunogenic profile enhances clinical safety. Dramatically
 improved hyaluronan degradation rate and thermal stability

 for superior reliability and performance.


Enables self-administered SC formulations,
removing the need for IV or hospital-based SC infusion.

CompanyExpressionActivityThemal
Stability		Immuno
genicitly
Company A+++Low
Company B++++++Low
Gene
Chem		+++++++++Low